|
|
S-adenosyl-L-methionine + (S)-Coclaurine <=> H+ + (S)-N-methylcoclaurine + S-adenosyl-L-homocysteine
|
2.1.1.115
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
2.1.1.140
(S)-coclaurine-N-methyltransferase
|
–
–
|
| |
BRENDA:
BR29467
KEGG:
R04692
MetaCyc:
2.1.1.140-RXN
|
|
|
|
H+ + L-tyrosine <=> CO2 + tyramine
|
4.1.1.25
tyrosine decarboxylase
4.1.1.28
aromatic-L-amino-acid decarboxylase
|
–
–
|
| |
BRENDA:
BR286
KEGG:
R00736
MetaCyc:
TYROSINE-DECARBOXYLASE-RXN
SABIO-RK:
1099
|
|
|
|
tyramine + tetrahydrobiopterin + O2 <=> dopamine + 4a-hydroxytetrahydrobiopterin
|
1.14.16.2
tyrosine 3-monooxygenase
|
–
|
| |
BRENDA:
BS417733
MetaCyc:
RXN-9978
|
|
|
|
L-tyrosine + 2-oxoglutarate <=> 4-hydroxyphenylpyruvate + L-glutamate
|
2.6.1.1
aspartate transaminase
2.6.1.2
alanine transaminase
2.6.1.24
diiodotyrosine transaminase
2.6.1.27
tryptophan transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.49
dihydroxyphenylalanine transaminase
2.6.1.5
tyrosine transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.7
kynurenine---oxoglutarate transaminase
2.6.1.79
glutamate---prephenate aminotransferase
2.6.1.9
histidinol-phosphate transaminase
|
–
–
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR47696
KEGG:
R00734
MetaCyc:
TYROSINE-AMINOTRANSFERASE-RXN
SABIO-RK:
1097
|
|
|
|
S-adenosyl-L-methionine + (S)-3''-hydroxy-N-methylcoclaurine <=> H+ + S-adenosyl-L-homocysteine + (S)-reticuline
|
2.1.1.116
3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
2.1.1.128
(RS)-norcoclaurine 6-O-methyltransferase
|
–
–
|
| |
BRENDA:
BR1437
KEGG:
R03832
MetaCyc:
2.1.1.116-RXN
|
|
|
|
dopamine + 4-hydroxyphenylacetaldehyde <=> H2O + (S)-norcoclaurine
|
4.2.1.78
(S)-norcoclaurine synthase
|
–
|
| |
BRENDA:
BR455
KEGG:
R04305
MetaCyc:
S-NORLAUDANOSOLINE-SYNTHASE-RXN
|
|
|
|
L-tyrosine + O2 <=> L-Dopa
|
1.10.3.1
catechol oxidase
1.14.18.1
tyrosinase
|
–
–
|
| |
BRENDA:
BR50166
KEGG:
R00031;
R00731
MetaCyc:
RXN-5861
SABIO-RK:
1094;
622
|
|
|
|
S-adenosyl-L-methionine + (S)-norcoclaurine <=> H+ + S-adenosyl-L-homocysteine + (S)-Coclaurine
|
2.1.1.128
(RS)-norcoclaurine 6-O-methyltransferase
|
–
|
| |
BRENDA:
BS386680
KEGG:
R05123
MetaCyc:
2.1.1.128-RXN
|
|
|
|
H+ + L-Dopa <=> dopamine + CO2
|
4.1.1.22
histidine decarboxylase
4.1.1.25
tyrosine decarboxylase
4.1.1.28
aromatic-L-amino-acid decarboxylase
4.1.1.53
phenylalanine decarboxylase
|
–
–
–
–
|
| |
BRENDA:
BR287
KEGG:
R02080
MetaCyc:
RXN66-221
SABIO-RK:
2090
|
|
|
|
(S)-N-methylcoclaurine + O2 + reduced_[NADPH-hemoprotein_reductase] <=> (S)-3''-hydroxy-N-methylcoclaurine + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.14.102
N-methylcoclaurine 3'-monooxygenase
|
–
|
| |
MetaCyc:
1.14.13.71-RXN
|
|
|
|
4-hydroxyphenylpyruvate + H+ <=> 4-hydroxyphenylacetaldehyde + CO2
|
4.1.1.72
branched-chain-2-oxoacid decarboxylase
4.1.1.74
indolepyruvate decarboxylase
4.1.1.80
4-hydroxyphenylpyruvate decarboxylase
|
–
–
–
|
| |
BRENDA:
BR40592
KEGG:
R03341
MetaCyc:
4.1.1.80-RXN
|
|
